A microrna prognostic marker identified in acute leukemia
A microrna prognostic marker identified in acute leukemia Business,Business News,Business Opportunities The study by researchers at the Ohio State University ComprehensiveCancer Center -- Arthur G. James Cancer Hospital and Richard J.Solove Research Institute (OSUCCC -- James) found that whenmicroRNA-3151 (miR-3151) is overexpressed in CN-AML, the diseaseresponds poorly to treatment and patients experience shorterremissions and survival periods. This effect is independent ofother gene mutations that may be present in the cells. Additionally, miR-3151 is encoded within a gene called BAALC, whichitself is an independent marker of poor survival when overexpressedin CN-AML. The findings, published online in the journal Blood (and as a Plenary paper which represents the top 1 to 5 percent ofpapers published in the print edition of Blood ), provide new insights into the nature of AML and might in thefuture help determine the best therapy for individual patients andfurther persona...